The gut microbiota form a complex ecosystem in the gastrointestinal tract and are involved in shaping growth trajectories of children.
- Through generations of humans, the matrilineal line transfers the primordial birth microbiota. A healthy microbiome is one which is seen in case of those infants who have healthy weight-for-height Z-score-WHZ OR length-for-age Z- score-LAZ in low middle Income countries in the context of malnutrition2
- Factors which govern healthy microbiome are - vaginal delivery, breastfeeding, maternal health and nutrition3
Human microbiota are involved in various metabolic processes which regulate growth and most of it happens in first 1000 days of life. Disturbances in gut microbiota may negatively affect child growth.2
References:
- Durda-Masny M, Ciomborowska-Basheer J, Makałowska I, Szwed A. The Mediating Role of the Gut Microbiota in the Physical Growth of Children. Life (Basel). 2022;12(2):152. Published 2022 Jan 20. doi:10.3390/life12020152
- Robertson RC, Manges AR, Finlay BB, Prendergast AJ. The Human Microbiome and Child Growth - First 1000 Days and Beyond. Trends Microbiol. 2019;27(2):131- 147. doi:10.1016/j.tim.2018.09.008
- Dominguez-Bello MG, Godoy-Vitorino F, Knight R, Blaser MJ. Role of the microbiome in human development. Gut. 2019;68(6):1108-1114. doi:10.1136/gutjnl- 2018-317503
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