Human milk is considered as ‘gold standard’ as it is the best form of nutrition for infants. WHO and UNICEF recommend exclusive breastfeeding for the first 6 months of life with introduction of complementary food at 6 months of age and continuation of breastfeeding up to 2 years.1
Human milk composition is unique and acts as a complete source of energy, provides several nutrients which acts as bioactive components that are specifically adapted and formulated to support infant’s growth and development.2 Some of these bioactive compounds are human milk oligosaccharides, α-lactalbumin, lactoferrin, taurine, milk fat globule membrane, folates, polyamines, long-chain polyunsaturated fatty acids (DHA & ARA), prebiotics and probiotics etc.3
What are Human Milk
Oligosaccharides?
Human milk oligosaccharides (HMOs) have become a topic of research due to its nutritional and health benefits for almost a century.4
HMOs are natural occurring prebiotics found in abundance in human milk.
3rd Largest solid
component In human Milk4,5
HMO content of colostrum is around 20g/L which later drops to 12-15g/L in mature human milk4.
More than 1000 different oligosacharides are present in human milk5,6, of which around 162 different structures have been characterized.7 2’-Fucosyllactose (2’-FL) is the most predominant oligosaccharide present in human milk.8
- Fucosylation HMOs
- Non-Fucosylated HMOs
- Non-Fucosylated HMOs
HMOs are classified into 3 main types namely9
- Neutral N-containing or Non-fucosylated HMOs
- Neutral or Fucosylated HMOs
(e.g. 2’-Fucosyllactose) - Acidic or Sialylated HMOs
(e.g. 2’-Sialyllactose)
Each HMO has a unique profile which varies over time & is influenced by several factors4, 10
- WHO 2000
- Greer FR. et al. Pediatrics. 2008;121(1):183-9.
- Almeida CC. et al. Int J Food Sci. 2021 May 14;2021:8850080.
- Sprenger N. et al. J Hum Nutr Diet. 2022 Apr;35(2):280-299.
- Stahl B. et al. Anal Biochem. 1994;223(2):218-26.
- Thurl S. et al. Nutr Rev. 2017:920-33.
- Urashima. et al. Glycotechnol. 2018, 30, SJ11–SJ24.
- Erney RM. et al. J Pediatr Gastroenterol Nutr. 2000;30(2):181-92.
- Wiciński M. et al. Nutrients. 2020 Jan 20;12(1):266.
- Coppa GV. et al. Acta paediatrica. 1999;88(430):89-94.
- Zhang S. et al. Microb Cell Fact. 2021 Jul 21;20(1):140
Read Articles
scGOS/lcFOS (9:1) and 2’-FL Combination Mimics Structural Diversity of Infant Feeds
scGOS/lcFOS (9:1) and 2’-FL Combination Mimics Structural Diversity of Infant Feeds
Effect of Human Milk Oligosaccharides on Infant Gut
Effect of Human Milk Oligosaccharides on Infant Gut
Impact of Prebiotic Oligosaccharides on Local Immunity
Human milk oligosaccharides (HMO) contribute to developing beneficial intestinal microflora and building immunity.
Favorable Effect Of Prebiotic Oligosaccharides On Gut Microbiota
Favorable Effect Of Prebiotic Oligosaccharides On Gut Microbiota
Nutricia Pioneering Innovation
Videos
Publications
2'-fucosyllactose Is Well Tolerated In A 100% Whey, Partially Hydrolyzed Infant Formula With Bifidobacterium Lactis: A Randomized Controlled Trial
Author: Heidi M. Storm , Julie Shepard, Laura M. Czerkies, Brian Kineman, Sarah S. Cohen, Heidi Reichert, Ryan Carvalho.
Journal: Global Pediatric Health, Volume 6: 1–10, March 2019.
DOI: 10.1177/2333794X19833995
Efficacy And Safety Of Hydrolyzed Cow Milk And Amino Acid-derived Formulas In Infants With Cow Milk Allergy
Author: E Isolauri, Y Sütas, S Mäkinen-Kiljunen, S S Oja, R Isosomppi, K Turjanmaa
Journal: J Pediatr. 1995 Oct;127(4):550-7
DOI: 10.1016/s0022-3476(95)70111-7
PREBIOTICS, GUT,
IMMUNITY & MORE
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