Among all the microbes that may be found in humans, the gut microbiota is the most numerous, diverse, and well-studied. 1
The three main functions of the gut microbiota, are protective, metabolic, and trophic. The colonisation of the gut by microbes starts at birth and lasts until age three. 1
Factors that have an impact on infant gut microbiome
Infant microbiota is altered throughout the first three years of life by the gut-brain axis, maternal and neonatal exposures, including antibiotic exposure, delivery method, and feeding habits. 1
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An imbalance between commensal and pathogenic organisms in the gut environment, known as gut dysbiosis, can be harmful to health and increase vulnerability to immunological-related pathogenic states as well as other unfavourable metabolic and immune outcomes.
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Gut microbiota influences immunity and helps to avoid disease in the early stages of development, but these interactions can also be pathogenic and result in illness. 2 Understanding the mechanisms by which the gut microbiota interacts with immune regulation, the endocrine system, and metabolism may aid in the development of strategies to direct the health-promoting microbiota that may be maintained throughout the lifespan.1
References:
- Yang I, Corwin EJ, Brennan PA, Jordan S, Murphy JR, Dunlop A. The Infant Microbiome: Implications for Infant Health and Neurocognitive Development. Nurs Res. 2016 Jan-Feb;65(1):76-88. doi: 10.1097/NNR.0000000000000133. PMID: 26657483; PMCID: PMC4681407.
- Al-Judaibi AA. Microbiota and their Influence in the Human Body. J Pure Appl Microbiol. 2021;15(1):42-52. doi:10.22207/ JPAM.15.1.27
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